Use of esters of N-hydroxysuccinimide in the synthesis of N-acylamino acids

Abstract

Several crystalline N-hydroxysuccinimide esters of short- and long-chain fatty acids have been synthesized. These compounds react with free amino acids to form preferentially N-acylamino acids. The reaction of the N-hydroxysuccinimide esters with hydroxylamine and the behavior of the N-acylamino acids on thin-layer chromatography are described.

Keywords

• lipoamino acids
• N-acylamino acids
• N-hydroxysuccinimide esters
• thin-layer chromatography