Nature Communications (Aug 2019)
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
- Yu Adachi,
- Keisuke Tonouchi,
- Arnone Nithichanon,
- Masayuki Kuraoka,
- Akiko Watanabe,
- Ryo Shinnakasu,
- Hideki Asanuma,
- Akira Ainai,
- Yusuke Ohmi,
- Takuya Yamamoto,
- Ken J. Ishii,
- Hideki Hasegawa,
- Haruko Takeyama,
- Ganjana Lertmemongkolchai,
- Tomohiro Kurosaki,
- Manabu Ato,
- Garnett Kelsoe,
- Yoshimasa Takahashi
Affiliations
- Yu Adachi
- Department of Immunology, National Institute of Infectious Diseases
- Keisuke Tonouchi
- Department of Immunology, National Institute of Infectious Diseases
- Arnone Nithichanon
- Department of Immunology, National Institute of Infectious Diseases
- Masayuki Kuraoka
- Department of Immunology, Duke University
- Akiko Watanabe
- Department of Immunology, Duke University
- Ryo Shinnakasu
- Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka University
- Hideki Asanuma
- Influenza Virus Research Center, National Institute of Infectious Diseases
- Akira Ainai
- Department of Pathology, National Institute of Infectious Diseases
- Yusuke Ohmi
- Department of Clinical Engineering, Chubu University College of Life and Health Sciences
- Takuya Yamamoto
- Laboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition
- Ken J. Ishii
- Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition
- Hideki Hasegawa
- Influenza Virus Research Center, National Institute of Infectious Diseases
- Haruko Takeyama
- Department of Life Science and Medical Bioscience, Waseda University
- Ganjana Lertmemongkolchai
- Center for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University
- Tomohiro Kurosaki
- Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka University
- Manabu Ato
- Department of Mycobacteriology, National Institute of Infectious Diseases
- Garnett Kelsoe
- Department of Immunology, Duke University
- Yoshimasa Takahashi
- Department of Immunology, National Institute of Infectious Diseases
- DOI
- https://doi.org/10.1038/s41467-019-11821-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Antibody cross-reactivity can help to prevent escape mutations from enabling viral escape, but underlying mechanisms are unclear. Here the authors identify influenza hemagglutinin epitopes that are exposed during viral replication and which result in the generation of a class of protective cross-reactive antibodies.
