Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

Chuangjia Huang; Chuangjia Huang; Xiaoling Guan; Xiaoling Guan; Hui Lin; Lu Liang; Lu Liang; Yingling Miao; Yingling Miao; Yueheng Wu; Huiqiong Bao; Xiaodan Wu; Xiaodan Wu; Ao Shen; Ao Shen; Minyan Wei; Minyan Wei; Jionghua Huang

doi:10.3389/fbioe.2021.762956

Frontiers in Bioengineering and Biotechnology (Nov 2021)

Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

Chuangjia Huang,
Chuangjia Huang,
Xiaoling Guan,
Xiaoling Guan,
Hui Lin,
Lu Liang,
Lu Liang,
Yingling Miao,
Yingling Miao,
Yueheng Wu,
Huiqiong Bao,
Xiaodan Wu,
Xiaodan Wu,
Ao Shen,
Ao Shen,
Minyan Wei,
Minyan Wei,
Jionghua Huang

Affiliations

Chuangjia Huang: Department of Cardiology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Chuangjia Huang: Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Xiaoling Guan: Department of Cardiology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Xiaoling Guan: Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Hui Lin: Department of Oncology, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Foshan, China
Lu Liang: Department of Cardiology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Lu Liang: Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Yingling Miao: Department of Cardiology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Yingling Miao: Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Yueheng Wu: School of Medicine, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, South China University of Technology, Guangzhou, China
Huiqiong Bao: School of Medicine, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, South China University of Technology, Guangzhou, China
Xiaodan Wu: Department of Cardiology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Xiaodan Wu: Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Ao Shen: Department of Cardiology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Ao Shen: Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Minyan Wei: Department of Cardiology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Minyan Wei: Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Jionghua Huang: Department of Cardiology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China

DOI: https://doi.org/10.3389/fbioe.2021.762956
Journal volume & issue: Vol. 9

Abstract

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Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by poor photostability in water, rapid body clearance, and non-specificity. Herein, we fabricated a novel biomimetic nanoprobe by coating ICG-loaded mesoporous silica nanoparticles with the cancer cell membrane (namely, CMI) for PA imaging. This probe exhibited good dispersion, large loading efficiency, good biocompatibility, and homologous targeting ability to Hela cells in vitro. Furthermore, the in vivo and ex vivo PA imaging on Hela tumor-bearing nude mice demonstrated that CMI could accumulate in tumor tissue and display a superior PA imaging efficacy compared with free ICG. All these results demonstrated that CMI might be a promising contrast agent for PA imaging of cervical carcinoma.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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