Nature Communications (Apr 2018)
Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
- Elena Lazzeri,
- Maria Lucia Angelotti,
- Anna Peired,
- Carolina Conte,
- Julian A. Marschner,
- Laura Maggi,
- Benedetta Mazzinghi,
- Duccio Lombardi,
- Maria Elena Melica,
- Sara Nardi,
- Elisa Ronconi,
- Alessandro Sisti,
- Giulia Antonelli,
- Francesca Becherucci,
- Letizia De Chiara,
- Ricardo Romero Guevara,
- Alexa Burger,
- Beat Schaefer,
- Francesco Annunziato,
- Hans-Joachim Anders,
- Laura Lasagni,
- Paola Romagnani
Affiliations
- Elena Lazzeri
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- Maria Lucia Angelotti
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- Anna Peired
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- Carolina Conte
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- Julian A. Marschner
- Division of Nephrology, Medizinische Klinik and Poliklinik IV, Klinikum der LMU München
- Laura Maggi
- Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE)
- Benedetta Mazzinghi
- Nephrology Unit and Meyer Children’s University Hospital
- Duccio Lombardi
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- Maria Elena Melica
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- Sara Nardi
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- Elisa Ronconi
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- Alessandro Sisti
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- Giulia Antonelli
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- Francesca Becherucci
- Nephrology Unit and Meyer Children’s University Hospital
- Letizia De Chiara
- Nephrology Unit and Meyer Children’s University Hospital
- Ricardo Romero Guevara
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- Alexa Burger
- Institute of Molecular Life Sciences, University of Zurich
- Beat Schaefer
- Department of Oncology and Children’s Research Center, University Children’s Hospital
- Francesco Annunziato
- Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE)
- Hans-Joachim Anders
- Division of Nephrology, Medizinische Klinik and Poliklinik IV, Klinikum der LMU München
- Laura Lasagni
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- Paola Romagnani
- Department of Clinical and Experimental Biomedical Sciences, University of Florence
- DOI
- https://doi.org/10.1038/s41467-018-03753-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
The recovery of function upon acute kidney injury is thought to involve tubular cell dedifferentiation and proliferation. Here the authors show that Pax2+ progenitors regenerate tubules via cell division while other tubular cells support function recovery by undergoing hypertrophy through endoreplication.
