Hysterectomy as a part of cardiovascular continuum

Abstract

Aim. To study the stages of metabolic disorder progression after hysterectomy (HE). Material and methods. In total, 104 women (mean age 44,0±2,1 years) after supravaginal hysterectomy with intact ovaries were examined. The participants were divided into three main subgroups, according to the time since HE (1 year, 3 years, and 5 years). The comparison group (CG) included 25 women (mean age 43,0±1,6 years). The levels of blood pressure (BP), blood lipid profile, immuno-reactive insulin (IRI) and C-peptide in plasma (fasting level and the level after oral glucose tolerance test) were measured. Results. Longer time since HE was associated with a significant increase in body mass index, systolic and diastolic BP, basal and stimulated C-peptide levels, basal and stimulated ITI levels, as well as in total cholesterol (CH) and low-density lipoprotein CH, comparing to the CG. There parameters were significantly and directly correlated with the time since HE. Conclusion. Metabolic disturbances were more pronounced in patients with longer time since HE. This allowed to specify the stages of post-HE metabolic syndrome and to justify the strategy for post-HE patients’ management.

Keywords

• постгистерэктомический синдром
• хирургическая менопауза
• метаболический синдром
• дислипидемия
• артериальная гипертензия
• с-пептид