Nature Communications (Oct 2020)
Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants
- Jonas Weinmann,
- Sabrina Weis,
- Josefine Sippel,
- Warut Tulalamba,
- Anca Remes,
- Jihad El Andari,
- Anne-Kathrin Herrmann,
- Quang H. Pham,
- Christopher Borowski,
- Susanne Hille,
- Tanja Schönberger,
- Norbert Frey,
- Martin Lenter,
- Thierry VandenDriessche,
- Oliver J. Müller,
- Marinee K. Chuah,
- Thorsten Lamla,
- Dirk Grimm
Affiliations
- Jonas Weinmann
- Heidelberg University Hospital, Dept. of Infectious Diseases/Virology, Cluster of Excellence CellNetworks
- Sabrina Weis
- Heidelberg University Hospital, Dept. of Infectious Diseases/Virology, Cluster of Excellence CellNetworks
- Josefine Sippel
- Heidelberg University Hospital, Dept. of Infectious Diseases/Virology, Cluster of Excellence CellNetworks
- Warut Tulalamba
- Vrije Universiteit Brussel, Department of Gene Therapy & Regenerative Medicine
- Anca Remes
- University Hospital Schleswig-Holstein, Campus Kiel, Innere Medizin III
- Jihad El Andari
- Heidelberg University Hospital, Dept. of Infectious Diseases/Virology, Cluster of Excellence CellNetworks
- Anne-Kathrin Herrmann
- Heidelberg University Hospital, Dept. of Infectious Diseases/Virology, Cluster of Excellence CellNetworks
- Quang H. Pham
- Vrije Universiteit Brussel, Department of Gene Therapy & Regenerative Medicine
- Christopher Borowski
- University Hospital Schleswig-Holstein, Campus Kiel, Innere Medizin III
- Susanne Hille
- University Hospital Schleswig-Holstein, Campus Kiel, Innere Medizin III
- Tanja Schönberger
- Boehringer Ingelheim Pharma GmbH & Co. KG, Drug Discovery Sciences
- Norbert Frey
- University Hospital Schleswig-Holstein, Campus Kiel, Innere Medizin III
- Martin Lenter
- Boehringer Ingelheim Pharma GmbH & Co. KG, Drug Discovery Sciences
- Thierry VandenDriessche
- Vrije Universiteit Brussel, Department of Gene Therapy & Regenerative Medicine
- Oliver J. Müller
- University Hospital Schleswig-Holstein, Campus Kiel, Innere Medizin III
- Marinee K. Chuah
- Vrije Universiteit Brussel, Department of Gene Therapy & Regenerative Medicine
- Thorsten Lamla
- Boehringer Ingelheim Pharma GmbH & Co. KG, Drug Discovery Sciences
- Dirk Grimm
- Heidelberg University Hospital, Dept. of Infectious Diseases/Virology, Cluster of Excellence CellNetworks
- DOI
- https://doi.org/10.1038/s41467-020-19230-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Adeno-associated virus is the basis of many gene therapies and gene transfer vectors. Here the authors report a pipeline to enable side-by-side comparison of pre-selected capsids in a high throughput manner.
