New Strategies of Inhibiting Malignant Tumor Based on Inducing Pyroptosis

Abstract

Pyroptosis is an atypical mode of cell programmed death, which is mainly manifested by pore formation, cell expansion, cell fluid outflow, secretion of inflammatory factors causing inflammatory response, and ultimately leading to cell disintegration after various external stimuli. Pyroptosis was first found in infectious diseases, but later found in the nervous system and cardiovascular system. Recent studies have also found that pyroptosis exists in tumors. It has become one of the hot research topics to explore its role in tumors. At present, studies have proposed that anti-cancer drugs, Chinese medicine monomers and so on can induce the pyroptosis of cancer cells. Therefore, this paper explores the impact molecules related to tumor cell pyroptosis, and summarizes its effect, then proposes two possible new strategies of preventing chemoresistance and regulating metabolic molecules.

Keywords

• pyroptosis
• malignant tumor
• chemotherapy
• metabolism
• strategy