Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response

Guoen Cai; Fabin Lin; Fabin Lin; Dihang Wu; Dihang Wu; Chenxin Lin; Chenxin Lin; Huiyun Chen; Yicong Wei; Huidan Weng; Zhiting Chen; Minxia Wu; En Huang; Zucheng Ye; Qinyong Ye

doi:10.3389/fphar.2022.859978

Frontiers in Pharmacology (May 2022)

Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response

Guoen Cai,
Fabin Lin,
Fabin Lin,
Dihang Wu,
Dihang Wu,
Chenxin Lin,
Chenxin Lin,
Huiyun Chen,
Yicong Wei,
Huidan Weng,
Zhiting Chen,
Minxia Wu,
En Huang,
Zucheng Ye,
Qinyong Ye

Affiliations

Guoen Cai: Department of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, China
Fabin Lin: Department of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, China
Fabin Lin: Department of Clinical Medicine, Fujian Medical University, Fuzhou, China
Dihang Wu: Department of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, China
Dihang Wu: Department of Clinical Medicine, Fujian Medical University, Fuzhou, China
Chenxin Lin: Department of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, China
Chenxin Lin: Department of Clinical Medicine, Fujian Medical University, Fuzhou, China
Huiyun Chen: Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China
Yicong Wei: College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China
Huidan Weng: Department of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, China
Zhiting Chen: Department of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, China
Minxia Wu: Public Technology Service Center, Fujian Medical University, Fuzhou, China
En Huang: Fujian Key Laboratory of Brain Aging and Neurodegenerative Diseases, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
Zucheng Ye: Fujian Key Laboratory of Brain Aging and Neurodegenerative Diseases, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
Qinyong Ye: Department of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, China

DOI: https://doi.org/10.3389/fphar.2022.859978
Journal volume & issue: Vol. 13

Abstract

Read online

Mitochondria are essential organelles that perform important roles in cell biologies such as ATP synthesis, metabolic regulation, immunomodulatory, and apoptosis. Parkinson’s disease (PD) is connected with mitochondrial neuronal damage related to mitochondrial unfolded protein response (mtUPR). Rosmarinic acid (RA) is a naturally occurring hydroxylated polyphenolic chemical found in the Boraginaceae and the Labiatae subfamily Nepetoideae. This study looked into RA’s protective effect against mitochondrial loss in the substantia nigra (SN) caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the underlying mechanism associated with the mtUPR. Pretreatment with RA reduced motor impairments and dopaminergic neuronal degeneration in the SN of a mouse model injected with MPTP. Pretreatment of SH-SY5Y cells from cell viability loss, morphological damage, and oxidative stress. Furthermore, RA pre-injection suppressed MPTP-induced mtUPR, lowered the expression of HSPA9, HSPE1, CLPP, LONP1, and SIRT 4, and protected the MPTP-mice and SH-SY5Y cells from mitochondrial failure. These findings imply that RA can prevent Parkinson’s disease by preventing mitochondrial damage in dopaminergic neurons in Parkinson’s disease via alleviating mitochondrial unfolded protein response.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

About the journal

Abstract

Keywords