BMC Research Notes (Sep 2008)

Absence of human herpes virus-8 (HHV8) in nephrogenic systemic fibrosis

  • Pantanowitz Liron,
  • Duke Wayne H,
  • O'Donnell Patrick J

DOI
https://doi.org/10.1186/1756-0500-1-82
Journal volume & issue
Vol. 1, no. 1
p. 82

Abstract

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Abstract Background Nephrogenic systemic fibrosis (NSF) is a fibrosing disorder that exhibits CD34 expression in the majority of lesional spindle cells. Several features of NSF bear similarity to Kaposi sarcoma. Findings Skin lesions procured from two male NSF patients were found to be negative for HHV8 (LNA-1) by means of immunohistochemsitry. Conclusion This finding negates a role for HHV8 in the pathogenesis of NSF.