IgG4-related disease and prostate cancer: A case report and review of the literature

Adam Zekhnini; Daniel Taussky; Jean-Baptiste Lattouf; Martial Koenig

Urology Case Reports (Sep 2023)

IgG4-related disease and prostate cancer: A case report and review of the literature

Adam Zekhnini,
Daniel Taussky,
Jean-Baptiste Lattouf,
Martial Koenig

Affiliations

Adam Zekhnini: Department of Radiation Oncology, Centre hospitalier de l’Université de Montréal, Montréal, Canada
Daniel Taussky: Department of Radiation Oncology, Centre hospitalier de l’Université de Montréal, Montréal, Canada; Corresponding author. Centre Hospitalier de l’Université de Montréal, Department of radiation oncology, 1000 rue St Denis, Montreal, Quebec, H2X 0C1, Canada.
Jean-Baptiste Lattouf: Division of Urology, Department of Surgery, Centre Hospitalier de l’Université de Montréal (CHUM), Montréal, Canada
Martial Koenig: Internal Medicine Service, Centre hospitalier Universitaire de Montréal (CHUM), Montréal, Québec, Canada

Journal volume & issue: Vol. 50
p. 102538

Abstract

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We present a case of a patient with recurrent prostate cancer after treatment for favorable intermediate risk cancer. There was an exceptionally steep increase in PSA from <0.5 to 130ng/mL in 27 months accompanied with the development of bone metastasis. The PSA increase was unexpected. We suspect that this unusual development of metastases must have been caused by an impairment of the immune system caused by his IgG4 disease, and this may have allowed residual prostate cancer cells in the prostate to spread quickly. The influence of IgG4 on cancer is debated.

Published in Urology Case Reports

ISSN: 2214-4420 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: http://www.urologycasereports.com/

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Abstract

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