Severe ovarian hyperstimulation syndrome requiring recurrent large-volume paracenteses until 21 weeks’ gestation: a case report
Chelsea A. Henshaw, M.D.,
Gregory W. Kirschen, M.D., Ph.D.,
Lucy Chen, M.D.,
Arthur J. Vaught, M.D.,
Katie Cameron, M.D.,
Mindy Christianson, M.D.
Affiliations
Chelsea A. Henshaw, M.D.
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland; Reprint requests: Chelsea A. Henshaw, M.D., Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, 600 North Wolfe St, Phipps 279 GynOb, Baltimore, Maryland 21287.
Gregory W. Kirschen, M.D., Ph.D.
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland
Lucy Chen, M.D.
Department of Gynecology and Obstetrics—Reproductive Endocrinology and Infertility, Johns Hopkins University School of Medicine, Baltimore, Maryland
Arthur J. Vaught, M.D.
Department of Gynecology and Obstetrics—Maternal Fetal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Katie Cameron, M.D.
Department of Gynecology and Obstetrics—Reproductive Endocrinology and Infertility, Johns Hopkins University School of Medicine, Baltimore, Maryland
Mindy Christianson, M.D.
Department of Gynecology and Obstetrics—Reproductive Endocrinology and Infertility, Johns Hopkins University School of Medicine, Baltimore, Maryland
Objective: To report a case of severe ovarian hyperstimulation syndrome (OHSS) persisting into the late second trimester of a singleton pregnancy. Design: Case report. Setting: Academic tertiary care center. Patient(s): A 29-year-old woman with severe OHSS after fresh embryo transfer after controlled ovarian hyperstimulation requiring intervention until 21 weeks’ gestation in a singleton pregnancy. Intervention(s): Thorough evaluation of an unusual case of severe OHSS and medical/procedural management of its sequelae in the setting of ongoing pregnancy. Main Outcome Measures(s): The clinical development of severe OHSS during pregnancy and its effect on pregnancy outcomes. Result(s): Severe OHSS persisted until 21 weeks’ gestation with reaccumulating ascitic fluid, which impacted pregnancy outcomes. Conclusion(s): Clinicians should be aware of the risk of severe OHSS and its possible effect on pregnancy outcomes beyond the first trimester.
