Nature Communications (Aug 2021)
Detection and characterization of lung cancer using cell-free DNA fragmentomes
- Dimitrios Mathios,
- Jakob Sidenius Johansen,
- Stephen Cristiano,
- Jamie E. Medina,
- Jillian Phallen,
- Klaus R. Larsen,
- Daniel C. Bruhm,
- Noushin Niknafs,
- Leonardo Ferreira,
- Vilmos Adleff,
- Jia Yuee Chiao,
- Alessandro Leal,
- Michael Noe,
- James R. White,
- Adith S. Arun,
- Carolyn Hruban,
- Akshaya V. Annapragada,
- Sarah Østrup Jensen,
- Mai-Britt Worm Ørntoft,
- Anders Husted Madsen,
- Beatriz Carvalho,
- Meike de Wit,
- Jacob Carey,
- Nicholas C. Dracopoli,
- Tara Maddala,
- Kenneth C. Fang,
- Anne-Renee Hartman,
- Patrick M. Forde,
- Valsamo Anagnostou,
- Julie R. Brahmer,
- Remond J. A. Fijneman,
- Hans Jørgen Nielsen,
- Gerrit A. Meijer,
- Claus Lindbjerg Andersen,
- Anders Mellemgaard,
- Stig E. Bojesen,
- Robert B. Scharpf,
- Victor E. Velculescu
Affiliations
- Dimitrios Mathios
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Jakob Sidenius Johansen
- Department of Oncology, Herlev and Gentofte Hospital
- Stephen Cristiano
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Jamie E. Medina
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Jillian Phallen
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Klaus R. Larsen
- Department of Respiratory Medicine, Infiltrate Unit, Bispebjerg Hospital
- Daniel C. Bruhm
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Noushin Niknafs
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Leonardo Ferreira
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Vilmos Adleff
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Jia Yuee Chiao
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Alessandro Leal
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Michael Noe
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- James R. White
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Adith S. Arun
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Carolyn Hruban
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Akshaya V. Annapragada
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Sarah Østrup Jensen
- Department of Molecular Medicine, Aarhus University Hospital
- Mai-Britt Worm Ørntoft
- Department of Molecular Medicine, Aarhus University Hospital
- Anders Husted Madsen
- Department of Surgery, Herning Regional Hospital
- Beatriz Carvalho
- Department of Pathology, The Netherlands Cancer Institute
- Meike de Wit
- Department of Pathology, The Netherlands Cancer Institute
- Jacob Carey
- Delfi Diagnostics
- Nicholas C. Dracopoli
- Delfi Diagnostics
- Tara Maddala
- Delfi Diagnostics
- Kenneth C. Fang
- Delfi Diagnostics
- Anne-Renee Hartman
- Delfi Diagnostics
- Patrick M. Forde
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Valsamo Anagnostou
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Julie R. Brahmer
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Remond J. A. Fijneman
- Department of Pathology, The Netherlands Cancer Institute
- Hans Jørgen Nielsen
- Department of Surgical Gastroenterology 360, Hvidovre Hospital
- Gerrit A. Meijer
- Department of Pathology, The Netherlands Cancer Institute
- Claus Lindbjerg Andersen
- Department of Surgery, Herning Regional Hospital
- Anders Mellemgaard
- Department of Oncology, Herlev and Gentofte Hospital
- Stig E. Bojesen
- Department of Clinical Biochemistry, Herlev and Gentofte Hospital
- Robert B. Scharpf
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Victor E. Velculescu
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-24994-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
DNA from tumour cells can be detected in the blood of cancer patients. Here, the authors show that cell free DNA fragmentation patterns can identify lung cancer patients and when this information is further interrogated it can be used to predict lung cancer histological subtype.
