Frontiers in Psychiatry (Jul 2018)

Cerebellar Structural Abnormalities Associated With Cognitive Function in Patients With First-Episode Psychosis

  • Taekwan Kim,
  • Kwang-Hyuk Lee,
  • Hyerim Oh,
  • Tae Young Lee,
  • Kang Ik K. Cho,
  • Kang Ik K. Cho,
  • Junhee Lee,
  • Jun Soo Kwon,
  • Jun Soo Kwon,
  • Jun Soo Kwon

DOI
https://doi.org/10.3389/fpsyt.2018.00286
Journal volume & issue
Vol. 9

Abstract

Read online

Introduction: The fundamental role of the cerebellum in higher cognitive processing has recently been highlighted. However, inconsistent findings exist in schizophrenia with respect to the exact nature of cerebellar structural abnormalities and their associations with cognitive and clinical features.Materials and Methods: We undertook a detailed investigation of cerebellar lobular volumes in 40 patients with first-episode psychosis (FEP) and 40 healthy controls (HCs) using the spatially unbiased atlas template of the cerebellum (SUIT). We examined the functional significance of cerebellar structural abnormalities in relation to cognitive and clinical outcomes in patients.Results: We found that left cerebellar lobules VI and X volumes were lower in FEP patients, compared to HCs. Smaller left lobules VI and X volumes were associated with fewer number of categories completed on the Wisconsin Card Sorting Test (WCST) in patients. In addition, smaller left lobule X volume was related to performance delay on the Trail Making Test (TMT) Part B in patients.Conclusion: Our results demonstrate that cerebellar structural abnormalities are present at the early stage of schizophrenia. We suggest functional associations of cerebellar structural changes with non-verbal executive dysfunctions in FEP.

Keywords