Гинекология (Dec 2016)
Experience of using the local combination product containing miconazole and metronidazole for the treatment of bacterial vaginosis and vulvovaginal candidiasis in pregnant women
Abstract
The problem of vaginal infections, such as bacterial vaginosis and vulvovaginal candidiasis during pregnancy is extremely relevant in connection with adverse perinatal outcomes, and an increased risk of preterm birth. Treatment of vaginal infections is a serious problem in connection with the formation of bacterial resistance, frequent recurrence, late onset of therapy due to the prolonged diagnosis and drug selection. We conducted a prospective study to evaluate the efficacy and safety of topical formulation containing 750 mg of metronidazole and 200 mg of miconazole nitrate (Neo-Penotran Forte) for the treatment of bacterial vaginosis and vulvovaginal candidiasis in pregnant women in II trimester. Methods. The study included 122 pregnant women aged 18 to 40 years (mean age 29.6±2.5 years) without concomitant extragenital pathology in 18-22 weeks gestation with a confirmed diagnosis of bacterial vaginosis (n=51) and candidiasis vulvovaginitis (n=71). The clinical and therapeutic efficacy of the drug was evaluated, as well as the speed of the onset of clinical efficacy (the day of the start of treatment), perinatal outcomes, the incidence of preterm delivery in both groups, the incidence of side effects during treatment with the drug. Results. The therapeutic efficiency of the preparation (no normalization of subjective symptoms and laboratory values) in a group of pregnant women with bacterial vaginosis at 14 and 28 days from the start of the study was 96% (n=48) and 94% (n=47), respectively. In the group with candidal vulvovaginitis - 94.2% (n=65) and 91.3% (n=63). Clinical efficacy (lack of subjective symptoms) by the end of the course of treatment achieved completely in all patients in both groups, and in many patients before the end of the full course of treatment. Conclusion. Neo-Penotran Forte is a highly effective and safe and can be recommended for the treatment of bacterial vaginosis and vulvovaginal candidiasis in pregnant women, starting with the II trimester. Effective treatment of pregnant women with bacterial vaginosis and vulvovaginal candidiasis drug Neo- Penotran Forte prevent adverse pregnancy outcomes and reduces the risk of preterm birth associated with vaginal infection, but due to the small sample size, this problem requires further investigation.
