Frontiers in Neurology (Jan 2022)

Glymphatic Dysfunction in Patients With End-Stage Renal Disease

  • Chang Min Heo,
  • Won Ho Lee,
  • Bong Soo Park,
  • Yoo Jin Lee,
  • Sihyung Park,
  • Yang Wook Kim,
  • Dong Ah Lee,
  • Byeong Cheol Yoo,
  • Kang Min Park

DOI
https://doi.org/10.3389/fneur.2021.809438
Journal volume & issue
Vol. 12

Abstract

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BackgroundWe aimed to compare glymphatic dysfunction between patients with end-stage renal disease (ESRD) and healthy controls and analyze the correlation between the glymphatic function and clinical characteristics using the diffusion tensor image analysis along with the perivascular space (DTI-ALPS) index.MethodsWe prospectively enrolled neurologically asymptomatic 49 patients with ESRD undergoing dialysis and 38 healthy controls. Diffusion tensor image was conducted using the same 3T scanner, and the DTI-ALPS index was calculated. We compared the DTI-ALPS index between the patients with ESRD and healthy controls. In addition, we conducted a correlation analysis between the clinical characteristics and DTI-ALPS index in patients with ESRD.ResultsThere were significant differences in the DTI-ALPS index between patients with ESRD and healthy controls. The DTI-ALPS index in patients with ESRD was lower than that in healthy controls (1.460 vs. 1.632, p = 0.003). In addition, there was a significant positive correlation between the DTI-ALPS index and serum parathyroid hormone levels (r = 0.357, p = 0.011).ConclusionWe demonstrated glymphatic dysfunction in patients with ESRD, as revealed by the DTI-ALPS index. This study also reveals the feasibility of the DTI-ALPS method to determine glymphatic function in patients with ESRD, which could be used in future research studies.

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