Cells (Aug 2022)

Skin-Aging Pigmentation: Who Is the Real Enemy?

  • Jin Cheol Kim,
  • Tae Jun Park,
  • Hee Young Kang

DOI
https://doi.org/10.3390/cells11162541
Journal volume & issue
Vol. 11, no. 16
p. 2541

Abstract

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Skin aging is induced and sustained by chronological aging and photoaging. Aging skin pigmentation such as mottled pigmentation (senile lentigo) and melasma are typical signs of photoaging. The skin, like other human organs, undergoes cellular senescence, and senescent cells in the skin increase with age. The crosstalk between melanocytes as pigmentary cells and other adjacent types of aged skin cells such as senescent fibroblasts play a role in skin-aging pigmentation. In this review, we provide an overview of cellular senescence during the skin-aging process. The discussion also includes cellular senescence related to skin-aging pigmentation and the therapeutic potential of regulating the senescence process.

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