The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1

Ashna Dhoonmoon; Claudia M. Nicolae; George-Lucian Moldovan

doi:10.1038/s41467-022-32756-5

Nature Communications (Aug 2022)

The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1

Ashna Dhoonmoon,
Claudia M. Nicolae,
George-Lucian Moldovan

Affiliations

Ashna Dhoonmoon: Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine
Claudia M. Nicolae: Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine
George-Lucian Moldovan: Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine

DOI: https://doi.org/10.1038/s41467-022-32756-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Protection of replication forks against nucleolytic degradation is crucial for genome stability. Here, Dhoonmoon et al identify PARP14 and the KU complex as essential regulators of fork degradation by MRE11 and EXO1 nucleases in BRCA-deficient cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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