Recent advances of Au@Ag core–shell SERS‐based biosensors

Gul Awiaz; Jie Lin; Aiguo Wu

doi:10.1002/EXP.20220072

Exploration (Feb 2023)

Recent advances of Au@Ag core–shell SERS‐based biosensors

Gul Awiaz,
Jie Lin,
Aiguo Wu

Affiliations

Gul Awiaz: Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering, CAS Ningbo China
Jie Lin: Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering, CAS Ningbo China
Aiguo Wu: Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering, CAS Ningbo China

DOI: https://doi.org/10.1002/EXP.20220072
Journal volume & issue: Vol. 3, no. 1
pp. n/a – n/a

Abstract

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Abstract The methodological advancements in surface‐enhanced Raman scattering (SERS) technique with nanoscale materials based on noble metals, Au, Ag, and their bimetallic alloy Au–Ag, has enabled the highly efficient sensing of chemical and biological molecules at very low concentration values. By employing the innovative various type of Au, Ag nanoparticles and especially, high efficiency Au@Ag alloy nanomaterials as substrate in SERS based biosensors have revolutionized the detection of biological components including; proteins, antigens antibodies complex, circulating tumor cells, DNA, and RNA (miRNA), etc. This review is about SERS‐based Au/Ag bimetallic biosensors and their Raman enhanced activity by focusing on different factors related to them. The emphasis of this research is to describe the recent developments in this field and conceptual advancements behind them. Furthermore, in this article we apex the understanding of impact by variation in basic features like effects of size, shape varying lengths, thickness of core–shell and their influence of large‐scale magnitude and morphology. Moreover, the detailed information about recent biological applications based on these core–shell noble metals, importantly detection of receptor binding domain (RBD) protein of COVID‐19 is provided.

Published in Exploration

ISSN: 2766-8509 (Print); 2766-2098 (Online)
Publisher: Wiley
Country of publisher: Australia
LCC subjects: Technology: Chemical technology: Biotechnology
Website: https://onlinelibrary.wiley.com/journal/27662098

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Abstract

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