Role of complement C3 in diabetic nephropathy

Abstract

As one of the most common microvascular complications of diabetes， diabetic kidney disease （DKD） is one of the major causes of end-stage renal disease. Complement system participates in both innate and adaptive immunities of human body. Three pathways of complement system intercross between complements C3 and C5 and complement C3 occupies a central position in complement system. This review summarized the possible mechanisms of complement C3 involved in the pathogenesis and progression of DKD.

Keywords

• Diabetes mellitus
• Diabetic kidney disease
• Complement C3