Proceedings (Aug 2017)

Differential Inductive Sensor for Continuous Non-Invasive Cell Growth Monitoring in Disposable Bioreactors

  • Maria Allers,
  • Tobias Reinecke,
  • Tamanna Nagraik,
  • Dörte Solle,
  • Kai Bakes,
  • Marc Berger,
  • Thomas Scheper,
  • Stefan Zimmermann

DOI
https://doi.org/10.3390/proceedings1040518
Journal volume & issue
Vol. 1, no. 4
p. 518

Abstract

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In this work, we present a low-cost sensor system for continuous non-invasive cell growth monitoring, especially for single use bioreactor (SUB) applications. The sensor system is based on a differential transformer. Using this differential setup, the influence of the primary magnetic flux is eliminated from the measuring signal, enabling highly sensitive non-invasive detection of permittivity changes in the culture medium. To evaluate the sensor, E. coli cultivations are performed and the cell density is measured through the polymer foil of a SUB. We found a linear dependency with low data scattering between measuring signal and cell density.

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