New Verticillene Diterpenoids, Eudesmane Sesquiterpenoids, and Hydroperoxysteroids from the Further Chemical Investigation of a Taiwanese Soft Coral <i>Cespitularia</i> sp.
Chung-Wei Fu,
You-Cheng Lin,
Shu-Fen Chiou,
Shu-Li Chen,
Chi-Chien Lin,
Hui-Chun Wang,
Chang-Feng Dai,
Jyh-Horng Sheu
Affiliations
Chung-Wei Fu
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
You-Cheng Lin
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Shu-Fen Chiou
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Shu-Li Chen
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Chi-Chien Lin
Institute of Biomedical Sciences, National Chung Hsing University, Taichung 402, Taiwan
Hui-Chun Wang
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Chang-Feng Dai
Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan
Jyh-Horng Sheu
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
An investigation of the chemical composition of a Formosan soft coral Cespitularia sp. led to the discovery of one new verticillene-type diterpenoid, cespitulactam M (1); one new eudesmane sesquiterpenoid, cespilamide F (2); and three new hydroperoxysteroids (3–5) along with twelve known analogous metabolites (6–17). In addition, one new derivative, cespitulactam M-6,2′-diacetate (1a), was prepared from compound 1. The structures were determined by detailed spectroscopic analyses, particularly HRESIMS and NMR techniques. Moreover, the in vitro cytotoxicity, anti-inflammatory, and antibacterial activity of 1–17 and 1a were evaluated.
