Diagnostic and prognostic role of NLR in testicular cancer

Shirin Sarejloo; Saghar Babadi; Shokoufeh Khanzadeh; Amirhossein Salimi; Alec Clark; Dinyar Khazaeli; Monireh Khanzadeh; Arshin Ghaedi; Brandon Lucke-Wold

doi:10.37349/etat.2024.00270

Exploration of Targeted Anti-tumor Therapy (Sep 2024)

Diagnostic and prognostic role of NLR in testicular cancer

Shirin Sarejloo,
Saghar Babadi,
Shokoufeh Khanzadeh,
Amirhossein Salimi,
Alec Clark,
Dinyar Khazaeli,
Monireh Khanzadeh,
Arshin Ghaedi,
Brandon Lucke-Wold

Affiliations

Shirin Sarejloo: Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz 767545, Iran
Saghar Babadi: Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz 868765, Iran
Shokoufeh Khanzadeh: Student Research Committee, Tabriz University of Medical Sciences, Tabriz 585658, Iran
Amirhossein Salimi: Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd 876576, Iran
Alec Clark: University of Central Florida College of Medicine, Orlando, FL 32608, USA
Dinyar Khazaeli: Urology Department, Imam Khomeini Hospital, Ahvaz 687667, Iran
Monireh Khanzadeh: Geriatric & Gerontology Department, Medical School, Tehran University of Medical and Health Sciences, Tehran 865476, Iran
Arshin Ghaedi: Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz 767545, Iran
Brandon Lucke-Wold: ORCiD; Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA

DOI: https://doi.org/10.37349/etat.2024.00270
Journal volume & issue: Vol. 5, no. 6
pp. 1177 – 1198

Abstract

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Background: To summarize the results of available studies for investigating the role of neutrophil to lymphocyte ratio (NLR) in testicular cancer (tCa). Methods: The search was conducted on PubMed, Scopus, and Web of Science up to November 21, 2021. Finally, a total of 31 studies were included in this review. Results: NLR was higher in tCa patients compared to healthy controls and benign testis pathologies, and decreased significantly after orchiectomy. An elevated NLR predicts poor prognosis, advanced stage, presence of nodal or distant metastases, contralateral tumor development, lower time-to-cancer specific death, worse OS, and poorer response to chemotherapy. However, NLR could not differentiate between seminomas and non-seminomatous tCa. Discussion: NLR has a significant diagnostic and prognostic value in tCa.

Published in Exploration of Targeted Anti-tumor Therapy

ISSN: 2692-3114 (Online)
Publisher: Open Exploration Publishing Inc.
Country of publisher: China
LCC subjects: Medicine: Internal medicine
Website: https://www.explorationpub.com/Journals/etat

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Abstract

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