Radiobioconjugate targeted therapy in cancer, using radiolabeled mediated biological analogs: Desired qualities and selective targeting approach

Abstract

Radiobioconjugate therapy, recommended as one of the effective modalities for the treatment of cancer cells, is based on the concept of delivering the localized radiation at the cellular level to the disease site using a biological moiety. The high tumor/nontumor ratio is the essentially a sine qua non for the successful execution of targeted therapy which is highly desired. The central problem associated to radiobioconjugate therapy is the small fraction of a radiobioconjugate localized to the tumor, while the major fraction of it is delivered to the nontarget organs (reticuloendothelial system deposition). The current article focuses on the better perceptive of the factors of understanding, which includes the selection and expansion of sophisticated molecular carriers, assortment of a suitable radionuclide based on the class of emission, linear energy transmit, and the material radiophysical half-life. In addition, a concern to the biochemical interactions taking place at the molecular level, selection of a specific targeting strategy for designing effective treatment regimes, and importantly the challenges associated to it have also been discussed.

Keywords

• antibody targeted therapy
• monoclonal antibody
• pretargeting strategies
• radiobioconjugate
• reticuloendothelial system uptake