Nature Communications (Sep 2019)
A novel role for the actin-binding protein drebrin in regulating opiate addiction
- Jennifer A. Martin,
- Craig T. Werner,
- Swarup Mitra,
- Ping Zhong,
- Zi-Jun Wang,
- Pedro H. Gobira,
- Andrew. F. Stewart,
- Jay Zhang,
- Kyra Erias,
- Justin N. Siemian,
- Devin Hagarty,
- Lauren E. Mueller,
- Rachael L. Neve,
- Jun-Xu Li,
- Ramesh Chandra,
- Karen C. Dietz,
- Mary Kay Lobo,
- Amy M. Gancarz,
- Zhen Yan,
- David M. Dietz
Affiliations
- Jennifer A. Martin
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- Craig T. Werner
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- Swarup Mitra
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- Ping Zhong
- Department of Physiology and Biophysics, The State University of New York at Buffalo
- Zi-Jun Wang
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- Pedro H. Gobira
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- Andrew. F. Stewart
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- Jay Zhang
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- Kyra Erias
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- Justin N. Siemian
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- Devin Hagarty
- Department of Psychology, California State University Bakersfield
- Lauren E. Mueller
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- Rachael L. Neve
- Gene Delivery Technology Core, Massachusetts General Hospital
- Jun-Xu Li
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- Ramesh Chandra
- Department of Anatomy and Neurobiology, University of Maryland School of Medicine
- Karen C. Dietz
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- Mary Kay Lobo
- Department of Anatomy and Neurobiology, University of Maryland School of Medicine
- Amy M. Gancarz
- Department of Psychology, California State University Bakersfield
- Zhen Yan
- Department of Physiology and Biophysics, The State University of New York at Buffalo
- David M. Dietz
- Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at Buffalo
- DOI
- https://doi.org/10.1038/s41467-019-12122-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
The underlying transcriptional and cellular events mediating the reduction of dendritic spines on medium spiny neurons of the nucleus accumbens (NAc) remains unknown. Here, authors demonstrate that heroin self-administration negatively regulates the actin-binding protein drebrin in the NAc, which is shown to be transcriptionally repressed by the histone modifier HDAC2, and that overexpression of drebrin is sufficient to decrease drug seeking and increase dendritic spine density
