Nature Communications (Jul 2020)
The induction and function of the anti-inflammatory fate of TH17 cells
- Hao Xu,
- Theodora Agalioti,
- Jun Zhao,
- Babett Steglich,
- Ramez Wahib,
- Maria Carolina Amezcua Vesely,
- Piotr Bielecki,
- Will Bailis,
- Ruaidhri Jackson,
- Daniel Perez,
- Jakob Izbicki,
- Paula Licona-Limón,
- Vesa Kaartinen,
- Jens Geginat,
- Enric Esplugues,
- Eva Tolosa,
- Samuel Huber,
- Richard A. Flavell,
- Nicola Gagliani
Affiliations
- Hao Xu
- Department of Immunobiology, School of Medicine, Yale University
- Theodora Agalioti
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Jun Zhao
- Department of Immunobiology, School of Medicine, Yale University
- Babett Steglich
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Ramez Wahib
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Maria Carolina Amezcua Vesely
- Department of Immunobiology, School of Medicine, Yale University
- Piotr Bielecki
- Department of Immunobiology, School of Medicine, Yale University
- Will Bailis
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Ruaidhri Jackson
- Department of Immunobiology, School of Medicine, Yale University
- Daniel Perez
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Jakob Izbicki
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Paula Licona-Limón
- Departamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México
- Vesa Kaartinen
- Biologic and Material Sciences, University of Michigan
- Jens Geginat
- INGM-National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi”
- Enric Esplugues
- Laboratory of Molecular and Cellular Immunology, Principe Felipe Research Center (CIPF)
- Eva Tolosa
- Institute of Immunology, University Medical Center Hamburg-Eppendorf
- Samuel Huber
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Richard A. Flavell
- Department of Immunobiology, School of Medicine, Yale University
- Nicola Gagliani
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/s41467-020-17097-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
CD4+ T helper cells producing IL-17A (TH17 cells) can take on pathogenic or anti-inflammatory functions in context-specific manners. Here the authors show that the anti-inflammatory fate of TH17 cells contributes, via TGF-β signaling and induction of IL-10, to host immune tolerance, but also simultaneously dampens protective immunity against S. aureus.
