A one-pot approach to novel α-trifluoromethylated coumarin-bearing tertiary alcohols promoted by CH3COOH/NH4OAc via consecutive ring-opening/aldol sequence

Abstract

A one-pot two-step reaction of 2-(trifluoromethyl)-2-hydroxy-2H-chromene with aryl ketone afforded α-trifluoromethylated tertiary alcohols bearing coumarins. The atomic economic and simply manipulative reaction involved premier treatment of reaction mixtures with CH3COOH and NH4OAc in one-pot process. The reaction proceeded to give the title compounds in moderate to good yields.

Keywords

• Coumarins
• Trifluoromethyl
• Tertiary alcohols
• One-pot approach