Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment

T. Einfalt; D. Witzigmann; C. Edlinger; S. Sieber; R. Goers; A. Najer; M. Spulber; O. Onaca-Fischer; J. Huwyler; C. G. Palivan

doi:10.1038/s41467-018-03560-x

Nature Communications (Mar 2018)

Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment

T. Einfalt,
D. Witzigmann,
C. Edlinger,
S. Sieber,
R. Goers,
A. Najer,
M. Spulber,
O. Onaca-Fischer,
J. Huwyler,
C. G. Palivan

Affiliations

T. Einfalt: Department of Chemistry, University of Basel
D. Witzigmann: Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel
C. Edlinger: Department of Chemistry, University of Basel
S. Sieber: Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel
R. Goers: Department of Chemistry, University of Basel
A. Najer: Department of Chemistry, University of Basel
M. Spulber: Department of Chemistry, University of Basel
O. Onaca-Fischer: Department of Chemistry, University of Basel
J. Huwyler: Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel
C. G. Palivan: Department of Chemistry, University of Basel

DOI: https://doi.org/10.1038/s41467-018-03560-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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The efficacy of stimuli-responsive enzyme delivery systems is usually limited to in vitro applications. Here the authors form artificial organelles by inserting stimuli-responsive protein gates in membranes of polymersomes loaded with enzymes and obtain a triggered functionality both in vitro and in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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