Clinical and Applied Thrombosis/Hemostasis (Jun 2024)

Efficacy and Safety of Rivaroxaban Versus Enoxaparin in Prevention of Recurrence of Venous Thrombo-Embolism Events in Cancer Patients: A Meta-Analysis

  • Abdul Rafeh Awan MBBS,
  • Abdullah Ahmad MBBS,
  • Muhammad Daniyal MBBS,
  • Malik Muhammad Hamza Khan MBBS,
  • Shaikh Jehanzaib Saeed MBBS,
  • Muhammad Bilal Siddiqui MBBS,
  • Sheraz Hakeem MBBS,
  • Azka Shahab MBBS,
  • Syed Hasham Ali MBBS,
  • Ahmed Kamal Siddiqi MBBS

DOI
https://doi.org/10.1177/10760296241261364
Journal volume & issue
Vol. 30

Abstract

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Objective To examine the effectiveness of rivaroxaban compared to enoxaparin in patients diagnosed with cancer and venous thromboembolism. Methods A search of Pub Med, Scopus, and Google Scholar, from inception through April 2023 was conducted. Articles comparing rivaroxaban with enoxaparin in patients with cancer and VTE/PE/DVT were included. Review Manager Version 5.2 was utilised for the analysis of the following outcomes; VTE, PE, DVT, major bleeding, and mortality. Results A total of 8 articles and 2276 patients were included in the final analysis. Pooled analysis showed that rivaroxaban had a statistically insignificant reduced association with VTE occurrence (RR:0.83, 95% CI:0.58–1.18, P:0.3) as well as a statically insignificant reduction in major bleeding (RR:0.79, 95% CI:0.53–1.18, P:0.25). Analysis showcased that there was an insignificant reduction of mortality rivaroxaban as compared to enoxaparin (RR:0.74, 95% CI: 0.46–1.20, P:0.23). Conclusion Rivaroxaban can serve as a viable alternative to enoxaparin, with no appreciable drawbacks, for preventing and managing VTE in patients with malignancy.