PLoS Genetics (Feb 2017)

The analysis of translation-related gene set boosts debates around origin and evolution of mimiviruses.

  • Jônatas Santos Abrahão,
  • Rodrigo Araújo,
  • Philippe Colson,
  • Bernard La Scola

DOI
https://doi.org/10.1371/journal.pgen.1006532
Journal volume & issue
Vol. 13, no. 2
p. e1006532

Abstract

Read online

The giant mimiviruses challenged the well-established concept of viruses, blurring the roots of the tree of life, mainly due to their genetic content. Along with other nucleo-cytoplasmic large DNA viruses, they compose a new proposed order-named Megavirales-whose origin and evolution generate heated debate in the scientific community. The presence of an arsenal of genes not widespread in the virosphere related to important steps of the translational process, including transfer RNAs, aminoacyl-tRNA synthetases, and translation factors for peptide synthesis, constitutes an important element of this debate. In this review, we highlight the main findings to date about the translational machinery of the mimiviruses and compare their distribution along the distinct members of the family Mimiviridae. Furthermore, we discuss how the presence and/or absence of the translation-related genes among mimiviruses raises important insights to boost the debate on their origin and evolutionary history.