Педиатрическая фармакология (May 2018)

Cytomegalovirus Infection in Infants: Course Variants, Modern Approaches to Therapy (Clinical Cases)

  • Irina A. Belyaeva,
  • Elena P. Bombardirova,
  • Tatiana V. Potekhina,
  • Aleksandra S. Gurskaya

DOI
https://doi.org/10.15690/pf.v15i2.1873
Journal volume & issue
Vol. 15, no. 2
pp. 168 – 174

Abstract

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Cytomegalovirus infection (CMVI) in newborns and infants can occur in various clinical forms requiring a differentiated therapy. We present the peculiarities of two different variants of CMVI course generalized with a manifest clinical picture and characteristic shifts in laboratory analyzes in a child aged 2.5 months with a combined genetic pathology, and latent intrauterine in a child aged 5 days leading to the development of neurosensory hearing loss. The difficulties in diagnosing a suppressed (latent) form of the disease and choosing a therapeutic approach have been highlighted. A successful result of etiopathogenetic therapy with ganciclovir in a child with postnatal generalized CMVI has been presented. The therapeutic efficacy and safety of off-label ganciclovir preparations and anti-cytomegalovirus immunoglobulin have been confirmed. The advisability of including ganciclovir in the management protocol of children with latent forms of CMVI is discussed.

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