Antifeedant Activities of Lignans from Stem Bark of Zanthoxylum armatum DC. against Tribolium castaneum

Wenjuan Zhang; Yang Wang; Zhufeng Geng; Shanshan Guo; Juqin Cao; Zhe Zhang; Xue Pang; Zhenyang Chen; Shushan Du; Zhiwei Deng

doi:10.3390/molecules23030617

Molecules (Mar 2018)

Antifeedant Activities of Lignans from Stem Bark of Zanthoxylum armatum DC. against Tribolium castaneum

Wenjuan Zhang,
Yang Wang,
Zhufeng Geng,
Shanshan Guo,
Juqin Cao,
Zhe Zhang,
Xue Pang,
Zhenyang Chen,
Shushan Du,
Zhiwei Deng

Affiliations

Wenjuan Zhang: Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, China
Yang Wang: Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, China
Zhufeng Geng: Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, China
Shanshan Guo: Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, China
Juqin Cao: Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, China
Zhe Zhang: Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, China
Xue Pang: Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, China
Zhenyang Chen: Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, China
Shushan Du: Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, China
Zhiwei Deng: Analytical and Testing Center, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China

DOI: https://doi.org/10.3390/molecules23030617
Journal volume & issue: Vol. 23, no. 3
p. 617

Abstract

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The speciation of a methanolic extract of Zanthoxylum armatum stem bark has enabled the isolation and characterization of 11 known lignans. Among them, five compounds (6, 8–11) are reported in this plant for the first time. All of the chemical structures were elucidated on the basis of NMR spectral analysis. Additionally, their antifeedant activities against Tribolium castaneum were evaluated scientifically. Among them, asarinin (1), with an EC50 of 25.64 ppm, exhibited a much stronger antifeedant activity than the positive control, toosendanin (EC50 = 71.69 ppm). Moreover, fargesin (2), horsfieldin (3), and magnolone (10), with EC50 values of 63.24, 68.39, and 78.37 ppm, showed almost the same antifeedant activity as the positive control. From the perspective of structure-effectiveness relationship, compounds with the chemical group of methylenedioxy exhibited higher antifeedant activities and have potential to be developed into novel antifeedants or potential lead compounds to protect food and crops in storage.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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