PLoS ONE (Jan 2014)

Prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation.

  • Mariana Ferreira Leal,
  • Priscila Daniele Ramos Cirilo,
  • Tatiane Katsue Furuya Mazzotti,
  • Danielle Queiroz Calcagno,
  • Fernanda Wisnieski,
  • Samia Demachki,
  • Margarita Cortes Martinez,
  • Paulo Pimentel Assumpção,
  • Roger Chammas,
  • Rommel Rodríguez Burbano,
  • Marília Cardoso Smith

DOI
https://doi.org/10.1371/journal.pone.0098583
Journal volume & issue
Vol. 9, no. 5
p. e98583

Abstract

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PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. The T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels. Moreover, the up-regulation of PHB appeared to be regulated by the gain of additional gene copies. Thus, PHB copy number variation and differential expression of the rs6917 polymorphism may play a role in PHB transcriptional regulation.