Frontiers in Oncology (Mar 2025)
The role and regulatory mechanism of lysosome associated protein transmembrane 4β in tumors
- Yuteng Yang,
- Yuteng Yang,
- Yuteng Yang,
- Yuteng Yang,
- Yuteng Yang,
- Yumei Li,
- Yumei Li,
- Yumei Li,
- Yumei Li,
- Yaqi Wang,
- Yaqi Wang,
- Yaqi Wang,
- Yaqi Wang,
- Xi Chen,
- Xi Chen,
- Xi Chen,
- Xi Chen,
- Yisong Yao,
- Yisong Yao,
- Yisong Yao,
- Yisong Yao,
- Dongxian Li,
- Dongxian Li,
- Dongxian Li,
- Dongxian Li,
- Guohua Yu,
- Guohua Yu,
- Guohua Yu,
- Guohua Yu,
- Xicheng Song,
- Xicheng Song,
- Xicheng Song,
- Xicheng Song
Affiliations
- Yuteng Yang
- The 2nd Medical College of Binzhou Medical University, Yantai, China
- Yuteng Yang
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Yuteng Yang
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Yuteng Yang
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Yuteng Yang
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Yumei Li
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Yumei Li
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Yumei Li
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Yumei Li
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Yaqi Wang
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Yaqi Wang
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Yaqi Wang
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Yaqi Wang
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Xi Chen
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Xi Chen
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Xi Chen
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Xi Chen
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Yisong Yao
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Yisong Yao
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Yisong Yao
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Yisong Yao
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Dongxian Li
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Dongxian Li
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Dongxian Li
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Dongxian Li
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Guohua Yu
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Guohua Yu
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Guohua Yu
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Guohua Yu
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Xicheng Song
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Xicheng Song
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Xicheng Song
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Xicheng Song
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- DOI
- https://doi.org/10.3389/fonc.2025.1552007
- Journal volume & issue
-
Vol. 15
Abstract
The oncogene LAPTM4B (encoding lysosome-associated protein transmembrane-4β), first cloned in hepatocellular carcinoma cells, is located on chromosome 8q22.1 and encodes two isoforms, LAPTM4B-35 and LAPTM4B-24. LAPTM4B proteins have four transmembrane structural domains and are mainly distributed in lysosomal and endosomal membranes of cells. Studies have shown that LAPTM4B is overexpressed in a variety of cancers, in which the genetic polymorphism of LAPTM4B is associated with tumor susceptibility. LAPTM4B also regulates various cell signaling pathways, interacts with autophagy-related proteins and ceramides, and regulates the autophagy process and the release of exosomes, which in turn affect the survival and drug resistance of tumor cells. In conclusion, this paper summarizes recent research on LAPTM4B, aiming to explore the role and potential mechanisms of LAPTM4B in a variety of tumors.
Keywords
