Hyaluronic acid preparations in the treatment of osteoarthritis. Synvisk®(Hylan G-F 20): Efficacy and safety

Abstract

The paper presents data on osteoarthrosis treatment using hyaluronic acid (HA) preparations, on the functions of hyaluronan (HN) in synovial fluid (SF), synovial tissue, and articular cartilage, and on differences in the symptom-modifying effect of HN with varying molecular weight. HN with average molecular weight demonstrates its benefits. The analgesic effect of HA preparations is shown to be determined by not only the improvement of SF elastoviscous properties and by the protection of pain receptors in joint tissues, but by their anti-rheumatic properties.

Keywords

• osteoporosis
• hyaluronan
• hyaluronic acid