The role of ROS-induced pyroptosis in CVD

Kaijiang Tian; Kaijiang Tian; Yu Yang; Kun Zhou; Nianhua Deng; Zhen Tian; Zefan Wu; Xiyan Liu; Fan Zhang; Zhisheng Jiang

doi:10.3389/fcvm.2023.1116509

Frontiers in Cardiovascular Medicine (Feb 2023)

The role of ROS-induced pyroptosis in CVD

Kaijiang Tian,
Kaijiang Tian,
Yu Yang,
Kun Zhou,
Nianhua Deng,
Zhen Tian,
Zefan Wu,
Xiyan Liu,
Fan Zhang,
Zhisheng Jiang

Affiliations

Kaijiang Tian: The First Affiliated Hospital of Hebei North University, Zhangjiakou, China
Kaijiang Tian: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang, China
Yu Yang: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang, China
Kun Zhou: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang, China
Nianhua Deng: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang, China
Zhen Tian: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang, China
Zefan Wu: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang, China
Xiyan Liu: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang, China
Fan Zhang: The First Affiliated Hospital of Hebei North University, Zhangjiakou, China
Zhisheng Jiang: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang, China

DOI: https://doi.org/10.3389/fcvm.2023.1116509
Journal volume & issue: Vol. 10

Abstract

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Cardiovascular disease (CVD) is the number one cause of death in the world and seriously threatens human health. Pyroptosis is a new type of cell death discovered in recent years. Several studies have revealed that ROS-induced pyroptosis plays a key role in CVD. However, the signaling pathway ROS-induced pyroptosis has yet to be fully understood. This article reviews the specific mechanism of ROS-mediated pyroptosis in vascular endothelial cells, macrophages, and cardiomyocytes. Current evidence shows that ROS-mediated pyroptosis is a new target for the prevention and treatment of cardiovascular diseases such as atherosclerosis (AS), myocardial ischemia-reperfusion injury (MIRI), and heart failure (HF).

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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Abstract

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