A Review on Solitary Fibrous Tumor Behavior in Pregnancy: A Case Report and Literature Review

Abstract

A solitary fibrous tumor (SFT) of the pleura is a rare chest wall mesenchymal neoplasm which usually arises from CD34-positive sub-mesothelial mesenchymal cells of visceral pleura. It is rare, accounting for less than 5% of all pleural neoplasms. Recently, steroid hormone receptors were recognized in the cells of extra-pleural SFT. Progesterone may participate as a growth factor in many CD34 (+) stromal neoplasms. During pregnancy, the amount of plasma progesterone gradually increases. As a result, it could promote the development of cancers that rely on progesterone. However, the link between SFT and pregnancy has not yet been established. There are only six extra-thoracic SFT-reported cases with accelerated growth during pregnancy, on the literature. Hence, we reported an interesting case of SFT which is the first reported case of thoracic SFT presenting during pregnancy. Moreover, we attempted to clarify the mechanism of this tumor's rapid growth by examining its hormonal receptors status in the cells of this tumor.

Keywords

• pleural neoplasms
• rapidly-growing mass
• diagnosis
• receptors
• steroid
• immunohistochemistry