The Novel Function of Unsymmetrical Chiral CCN Pincer Nickel Complexes as Chemotherapeutic Agents Targeting Prostate Cancer Cells
Jing-Jing Qu,
Lin-Lin Shi,
Yan-Bing Wang,
Jing Yan,
Tian Shao,
Xin-Qi Hao,
Jia-Xiang Wang,
Hong-Yu Zhang,
Jun-Fang Gong,
Bing Song
Affiliations
Jing-Jing Qu
College of Chemistry, School of Life Sciences, School of Basic Medical Science, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 100 of Science Road, Zhengzhou 450001, China
Lin-Lin Shi
College of Chemistry, School of Life Sciences, School of Basic Medical Science, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 100 of Science Road, Zhengzhou 450001, China
Yan-Bing Wang
College of Chemistry, School of Life Sciences, School of Basic Medical Science, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 100 of Science Road, Zhengzhou 450001, China
Jing Yan
College of Chemistry, School of Life Sciences, School of Basic Medical Science, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 100 of Science Road, Zhengzhou 450001, China
Tian Shao
College of Chemistry, School of Life Sciences, School of Basic Medical Science, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 100 of Science Road, Zhengzhou 450001, China
Xin-Qi Hao
College of Chemistry, School of Life Sciences, School of Basic Medical Science, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 100 of Science Road, Zhengzhou 450001, China
Jia-Xiang Wang
College of Chemistry, School of Life Sciences, School of Basic Medical Science, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 100 of Science Road, Zhengzhou 450001, China
Hong-Yu Zhang
College of Chemistry, School of Life Sciences, School of Basic Medical Science, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 100 of Science Road, Zhengzhou 450001, China
Jun-Fang Gong
College of Chemistry, School of Life Sciences, School of Basic Medical Science, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 100 of Science Road, Zhengzhou 450001, China
Bing Song
College of Chemistry, School of Life Sciences, School of Basic Medical Science, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 100 of Science Road, Zhengzhou 450001, China
We report that the pincer nickel complexes display prostate cancer antitumor properties through inhibition of cell proliferation. Notably, they display better antitumor properties than cisplatin. Mechanistic studies reveal that these pincer nickel complexes trigger cell apoptosis, most likely due to cell cycle arrest. Interestingly, these complexes also inhibit androgen receptor (AR) and prostate-specific antigen (PSA) signaling, which are critical for prostate cancer survival and progression. Our study reveals a novel function of pincer nickel complexes as potential therapeutic drugs in prostate cancer.
