A simple and efficient approach to the synthesis of 2-substituted benzimidazole via sp3 C–H functionalization

Abstract

A facile and novel approach to the synthesis of 2-substituted benzimidazole was developed via a tandem reaction following sp3 C–H functionalization. Here we report a simple, efficient and tandem oxidative dehydrative coupling reaction of N-benzylbezene-1,2-diamine in the presence of oxidant tert-butyl hydroperoxide (TBHP) in solvent acetonitrile to give substituted benzimidazole.

Keywords

• 2-Substituted benzimidazole
• Tandem reaction
• CDC (cross dehydrative coupling)