Nature Communications (Jun 2021)
A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome
- Perrine Soret,
- Christelle Le Dantec,
- Emiko Desvaux,
- Nathan Foulquier,
- Bastien Chassagnol,
- Sandra Hubert,
- Christophe Jamin,
- Guillermo Barturen,
- Guillaume Desachy,
- Valérie Devauchelle-Pensec,
- Cheïma Boudjeniba,
- Divi Cornec,
- Alain Saraux,
- Sandrine Jousse-Joulin,
- Nuria Barbarroja,
- Ignasi Rodríguez-Pintó,
- Ellen De Langhe,
- Lorenzo Beretta,
- Carlo Chizzolini,
- László Kovács,
- Torsten Witte,
- PRECISESADS Clinical Consortium,
- PRECISESADS Flow Cytometry Consortium,
- Eléonore Bettacchioli,
- Anne Buttgereit,
- Zuzanna Makowska,
- Ralf Lesche,
- Maria Orietta Borghi,
- Javier Martin,
- Sophie Courtade-Gaiani,
- Laura Xuereb,
- Mickaël Guedj,
- Philippe Moingeon,
- Marta E. Alarcón-Riquelme,
- Laurence Laigle,
- Jacques-Olivier Pers
Affiliations
- Perrine Soret
- Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development
- Christelle Le Dantec
- LBAI, UMR1227, Univ Brest, Inserm
- Emiko Desvaux
- Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development
- Nathan Foulquier
- LBAI, UMR1227, Univ Brest, Inserm
- Bastien Chassagnol
- Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development
- Sandra Hubert
- Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development
- Christophe Jamin
- LBAI, UMR1227, Univ Brest, Inserm
- Guillermo Barturen
- Department of Medical Genomics, Center for Genomics and Oncological Research (GENYO)
- Guillaume Desachy
- Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development
- Valérie Devauchelle-Pensec
- LBAI, UMR1227, Univ Brest, Inserm
- Cheïma Boudjeniba
- Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development
- Divi Cornec
- LBAI, UMR1227, Univ Brest, Inserm
- Alain Saraux
- LBAI, UMR1227, Univ Brest, Inserm
- Sandrine Jousse-Joulin
- LBAI, UMR1227, Univ Brest, Inserm
- Nuria Barbarroja
- Reina Sofia Hospital, Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), University of Cordoba
- Ignasi Rodríguez-Pintó
- Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi i Sunyer
- Ellen De Langhe
- Skeletal Biology and Engineering Research Center, KU Leuven and Division of Rheumatology
- Lorenzo Beretta
- Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico di Milano
- Carlo Chizzolini
- Immunology & Allergy, University Hospital and School of Medicine
- László Kovács
- University of Szeged
- Torsten Witte
- Klinik für Immunologie und Rheumatologie, Medical University Hannover
- PRECISESADS Clinical Consortium
- PRECISESADS Flow Cytometry Consortium
- Eléonore Bettacchioli
- CHU de Brest
- Anne Buttgereit
- Pharmaceuticals Division, Bayer Pharma Aktiengesellschaft
- Zuzanna Makowska
- Pharmaceuticals Division, Bayer Pharma Aktiengesellschaft
- Ralf Lesche
- Pharmaceuticals Division, Bayer Pharma Aktiengesellschaft
- Maria Orietta Borghi
- Università degli studi di Milano
- Javier Martin
- Institute of Parasitology and Biomedicine López-Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC)
- Sophie Courtade-Gaiani
- Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development
- Laura Xuereb
- Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development
- Mickaël Guedj
- Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development
- Philippe Moingeon
- Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development
- Marta E. Alarcón-Riquelme
- Department of Medical Genomics, Center for Genomics and Oncological Research (GENYO)
- Laurence Laigle
- Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development
- Jacques-Olivier Pers
- LBAI, UMR1227, Univ Brest, Inserm
- DOI
- https://doi.org/10.1038/s41467-021-23472-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Sjögren’s syndrome, a disease that primarily affects women, is poorly understood. Here, the authors combine data from a large cohort of patients and healthy controls to identify biomarkers that distinguish patient subgroups to improve our understanding of the disease and facilitate drug development.
