Role of Pituitary Tumour Transforming Gene 1 in Medullary Thyroid Carcinoma

Maria Chiara Zatelli; Federico Tagliati; Vincenzo Amodio; Mattia Buratto; Mariarosa Pelizzo; Giancarlo Pansini; Marta Bondanelli; Maria Rosaria Ambrosio; Ettore C. degli Uberti

doi:10.3233/ACP-CLO-2010-0536

Analytical Cellular Pathology (Jan 2010)

Role of Pituitary Tumour Transforming Gene 1 in Medullary Thyroid Carcinoma

Maria Chiara Zatelli,
Federico Tagliati,
Vincenzo Amodio,
Mattia Buratto,
Mariarosa Pelizzo,
Giancarlo Pansini,
Marta Bondanelli,
Maria Rosaria Ambrosio,
Ettore C. degli Uberti

Affiliations

Maria Chiara Zatelli: Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy
Federico Tagliati: Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy
Vincenzo Amodio: Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy
Mattia Buratto: Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy
Mariarosa Pelizzo: Department of Medical and Surgical Science, General Surgery III, University of Padua, Padua, Italy
Giancarlo Pansini: Section of General Surgery, Department of Surgery, University of Ferrara, Ferrara, Italy
Marta Bondanelli: Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy
Maria Rosaria Ambrosio: Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy
Ettore C. degli Uberti: Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy

DOI: https://doi.org/10.3233/ACP-CLO-2010-0536
Journal volume & issue: Vol. 33, no. 5-6
pp. 207 – 216

Abstract

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Background: Pituitary tumour transforming gene 1 (PTTG1) is over-expressed in a variety of endocrine-related tumours. We aimed at evaluating PTTG1 expression and function in human neoplastic parafollicular C-cells, represented by medullary thyroid carcinoma (MTC) and C-cell hyperplasia (CCH) samples and by the TT cell line.

Published in Analytical Cellular Pathology

ISSN: 2210-7177 (Print); 2210-7185 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://www.hindawi.com/journals/acp/

About the journal