Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses
Mark W. Russell,
Julie S. Moldenhauer,
Jack Rychik,
Nancy B. Burnham,
Erin Zullo,
Samuel I. Parry,
Rebecca A. Simmons,
Michal A. Elovitz,
Susan C. Nicolson,
Rebecca L. Linn,
Mark P. Johnson,
Sunkyung Yu,
Matthew G. Sampson,
Hakon Hakonarson,
J. William Gaynor
Affiliations
Mark W. Russell
Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA; Corresponding author.
Julie S. Moldenhauer
Center for Fetal Diagnosis and Therapy, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Jack Rychik
Division of Pediatric Cardiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Nancy B. Burnham
Division of Cardiothoracic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Erin Zullo
Division of Cardiothoracic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Samuel I. Parry
Division of Maternal Fetal Medicine, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA
Rebecca A. Simmons
Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Michal A. Elovitz
Division of Maternal Fetal Medicine, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA
Susan C. Nicolson
Division of Cardiothoracic Anesthesiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Rebecca L. Linn
Division of Anatomic Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Mark P. Johnson
Center for Fetal Diagnosis and Therapy, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Sunkyung Yu
Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA
Matthew G. Sampson
Division of Pediatric Nephrology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA; Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA
Hakon Hakonarson
The Center for Applied Genomics, The Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
J. William Gaynor
Division of Cardiothoracic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregnancies involving critical congenital cardiac defects (Russell et al., 2019). In this dataset, we present the specific genetic variants identified, describe the parental origin of each variant where possible and present the analyses regarding the potential effects of parental origin of the variant on placental function and fetal growth. The data presented are related to the research article “Damaging variants in pro-angiogenic genes impair growth in fetuses with cardiac defects” (Russell et al., 2019). Keywords: Genetic variation, Placental function, Fetal growth, Congenital cardiac defects
