Elastin biology and tissue engineering with adult cells

Saitow Cassandra B.; Wise Steven G.; Weiss Anthony S.; Castellot John J.; Kaplan David L.

doi:10.1515/bmc-2012-0040

Biomolecular Concepts (Apr 2013)

Elastin biology and tissue engineering with adult cells

Saitow Cassandra B.,
Wise Steven G.,
Weiss Anthony S.,
Castellot John J.,
Kaplan David L.

Affiliations

Saitow Cassandra B.: Tufts University, Department of Biomedical Engineering, Medford, MA, 02155, USA
Wise Steven G.
Weiss Anthony S.: Molecular Biosciences, University of Sydney, Sydney, New South Wales, Australia
Castellot John J.: Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, 02111, USA
Kaplan David L.: Tufts University, Department of Biomedical Engineering, Medford, MA, 02155, USA

DOI: https://doi.org/10.1515/bmc-2012-0040
Journal volume & issue: Vol. 4, no. 2
pp. 173 – 185

Abstract

Read online

The inability of adult cells to produce well-organized, robust elastic fibers has long been a barrier to the successful engineering of certain tissues. In this review, we focus primarily on elastin with respect to tissue-engineered vascular substitutes. To understand elastin regulation during normal development, we describe the role of various elastic fiber accessory proteins. Biochemical pathways regulating expression of the elastin gene are addressed, with particular focus on tissue-engineering research using adult-derived cells.

Published in Biomolecular Concepts

ISSN: 1868-5021 (Print); 1868-503X (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Biology (General)
Website: https://www.degruyter.com/view/j/bmc

About the journal

Abstract

Keywords