Nature Communications (Feb 2017)
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
- Chun-Hua Liu,
- Zheng Gong,
- Zong-Lai Liang,
- Zhi-Xin Liu,
- Fan Yang,
- Yu-Jing Sun,
- Ming-Liang Ma,
- Yi-Jing Wang,
- Chao-Ran Ji,
- Yu-Hong Wang,
- Mei-Jie Wang,
- Fu-Ai Cui,
- Amy Lin,
- Wen-Shuai Zheng,
- Dong-Fang He,
- Chang-xiu Qu,
- Peng Xiao,
- Chuan-Yong Liu,
- Alex R. B. Thomsen,
- Thomas Joseph Cahill,
- Alem W. Kahsai,
- Fan Yi,
- Kun-Hong Xiao,
- Tian Xue,
- Zhuan Zhou,
- Xiao Yu,
- Jin-Peng Sun
Affiliations
- Chun-Hua Liu
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- Zheng Gong
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- Zong-Lai Liang
- Department of Physiology, Shandong University School of Medicine
- Zhi-Xin Liu
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- Fan Yang
- Department of Physiology, Shandong University School of Medicine
- Yu-Jing Sun
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- Ming-Liang Ma
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- Yi-Jing Wang
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- Chao-Ran Ji
- Department of Physiology, Shandong University School of Medicine
- Yu-Hong Wang
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- Mei-Jie Wang
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- Fu-Ai Cui
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- Amy Lin
- Duke University, School of Medicine
- Wen-Shuai Zheng
- Department of Physiology, Shandong University School of Medicine
- Dong-Fang He
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- Chang-xiu Qu
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- Peng Xiao
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- Chuan-Yong Liu
- Department of Physiology, Shandong University School of Medicine
- Alex R. B. Thomsen
- Duke University, School of Medicine
- Thomas Joseph Cahill
- Duke University, School of Medicine
- Alem W. Kahsai
- Duke University, School of Medicine
- Fan Yi
- Department of Pharmacology, Shandong University School of Medicine
- Kun-Hong Xiao
- Duke University, School of Medicine
- Tian Xue
- Hefei National Laboratory for Physical Science at Microscale, School of Life Science, University of Science and Technology of China
- Zhuan Zhou
- Laboratory of Cellular Biophysics and Neurodegeneration, Ying-Jie Conference Center, Peking University
- Xiao Yu
- Department of Physiology, Shandong University School of Medicine
- Jin-Peng Sun
- Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms14335
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent calcium influx and catecholamine secretion.
