Nature Communications (May 2020)
Genomic landscape of platinum resistant and sensitive testicular cancers
- Chey Loveday,
- Kevin Litchfield,
- Paula Z. Proszek,
- Alex J. Cornish,
- Flavia Santo,
- Max Levy,
- Geoff Macintyre,
- Amy Holryod,
- Peter Broderick,
- Darshna Dudakia,
- Barbara Benton,
- Maise Al Bakir,
- Crispin Hiley,
- Emily Grist,
- Charles Swanton,
- Robert Huddart,
- Tom Powles,
- Simon Chowdhury,
- Janet Shipley,
- Simon O’Connor,
- James D. Brenton,
- Alison Reid,
- David Gonzalez de Castro,
- Richard S. Houlston,
- Clare Turnbull
Affiliations
- Chey Loveday
- Division of Genetics & Epidemiology, The Institute of Cancer Research
- Kevin Litchfield
- Division of Genetics & Epidemiology, The Institute of Cancer Research
- Paula Z. Proszek
- The Centre for Molecular Pathology, The Royal Marsden NHS Trust
- Alex J. Cornish
- Division of Genetics & Epidemiology, The Institute of Cancer Research
- Flavia Santo
- The Centre for Molecular Pathology, The Royal Marsden NHS Trust
- Max Levy
- Division of Genetics & Epidemiology, The Institute of Cancer Research
- Geoff Macintyre
- Cancer Research UK Cambridge Institute, University of Cambridge
- Amy Holryod
- Division of Genetics & Epidemiology, The Institute of Cancer Research
- Peter Broderick
- Division of Genetics & Epidemiology, The Institute of Cancer Research
- Darshna Dudakia
- Division of Genetics & Epidemiology, The Institute of Cancer Research
- Barbara Benton
- Division of Genetics & Epidemiology, The Institute of Cancer Research
- Maise Al Bakir
- Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute
- Crispin Hiley
- Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute
- Emily Grist
- Division of Molecular Pathology, The Institute of Cancer Research
- Charles Swanton
- Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute
- Robert Huddart
- Academic Radiotherapy Unit, Institute of Cancer Research
- Tom Powles
- Barts Cancer Institute, Queen Mary University
- Simon Chowdhury
- Department of Oncology, Guys and St Thomas’ NHS Foundation Trust
- Janet Shipley
- Division of Molecular Pathology, The Institute of Cancer Research
- Simon O’Connor
- The Centre for Molecular Pathology, The Royal Marsden NHS Trust
- James D. Brenton
- Cancer Research UK Cambridge Institute, University of Cambridge
- Alison Reid
- Academic Uro-oncology Unit, The Royal Marsden NHS Foundation Trust
- David Gonzalez de Castro
- Centre for Cancer Research and Cell Biology, Queen’s University Belfast
- Richard S. Houlston
- Division of Genetics & Epidemiology, The Institute of Cancer Research
- Clare Turnbull
- Division of Genetics & Epidemiology, The Institute of Cancer Research
- DOI
- https://doi.org/10.1038/s41467-020-15768-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Most testicular germ-cell tumours are exquisitely sensitive to platinum-based chemotherapies, but little is known about why 10% are resistant. Here, the authors explore the potential underlying mechanisms by probing the genomic landscape of platinum-resistant disease.
