Amyloid fibril structure from the vascular variant of systemic AA amyloidosis

Sambhasan Banerjee; Julian Baur; Christoph Daniel; Peter Benedikt Pfeiffer; Manuel Hitzenberger; Lukas Kuhn; Sebastian Wiese; Johan Bijzet; Christian Haupt; Kerstin U. Amann; Martin Zacharias; Bouke P. C. Hazenberg; Gunilla T. Westermark; Matthias Schmidt; Marcus Fändrich

doi:10.1038/s41467-022-34636-4

Nature Communications (Nov 2022)

Amyloid fibril structure from the vascular variant of systemic AA amyloidosis

Sambhasan Banerjee,
Julian Baur,
Christoph Daniel,
Peter Benedikt Pfeiffer,
Manuel Hitzenberger,
Lukas Kuhn,
Sebastian Wiese,
Johan Bijzet,
Christian Haupt,
Kerstin U. Amann,
Martin Zacharias,
Bouke P. C. Hazenberg,
Gunilla T. Westermark,
Matthias Schmidt,
Marcus Fändrich

Affiliations

Sambhasan Banerjee: Institute of Protein Biochemistry, Ulm University
Julian Baur: Institute of Protein Biochemistry, Ulm University
Christoph Daniel: Department of Nephropathology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Peter Benedikt Pfeiffer: Institute of Protein Biochemistry, Ulm University
Manuel Hitzenberger: Physics Department (T38), Technical University of Munich
Lukas Kuhn: Institute of Protein Biochemistry, Ulm University
Sebastian Wiese: Core Unit Mass Spectrometry and Proteomics, Ulm University
Johan Bijzet: Amyloidosis Center of Expertise, University Medical Center Groningen, University of Groningen
Christian Haupt: Institute of Protein Biochemistry, Ulm University
Kerstin U. Amann: Department of Nephropathology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Martin Zacharias: Physics Department (T38), Technical University of Munich
Bouke P. C. Hazenberg: Amyloidosis Center of Expertise, University Medical Center Groningen, University of Groningen
Gunilla T. Westermark: Department of Medical Cell Biology, Uppsala University
Matthias Schmidt: Institute of Protein Biochemistry, Ulm University
Marcus Fändrich: Institute of Protein Biochemistry, Ulm University

DOI: https://doi.org/10.1038/s41467-022-34636-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

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This study reports the cryo-EM structures of AA amyloid fibrils from two patients with vascular AA amyloidosis. The findings imply that different disease variants in systemic amyloidosis are associated with different fibril structures.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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