Research Progress of Paclitaxel Drug Source Solution and Extraction and Separation Technology

Abstract

Taxol, a natural secondary metabolite extracted from the bark of taxus chinensis, is one of the best natural anti-tumor drugs in the past decade and has great medicinal value. However, the content of paclitaxel in plant body is low, the extraction and separation are difficult, and the drug source is short. Based on the review of the literature on paclitaxel, this paper discusses and reviews the solutions of paclitaxel’s drug sources in terms of its synthesis, plant cell culture, endophytic fungi fermentation and synthetic biology. The research progress of paclitaxel extraction and separation technology and the possibility of large-scale industrial production were considered and prospected, which provided a reference for the solution of the drug source problem of paclitaxel and further study.