Nature Communications (Aug 2017)

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors

  • Kathryn F. Cogger,
  • Ankit Sinha,
  • Farida Sarangi,
  • Emily C. McGaugh,
  • Diane Saunders,
  • Craig Dorrell,
  • Salvador Mejia-Guerrero,
  • Yasaman Aghazadeh,
  • Jillian L. Rourke,
  • Robert A. Screaton,
  • Markus Grompe,
  • Philip R. Streeter,
  • Alvin C. Powers,
  • Marcela Brissova,
  • Thomas Kislinger,
  • M. Cristina Nostro

DOI
https://doi.org/10.1038/s41467-017-00561-0
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Pancreatic progenitors (PPs) can be derived from human pluripotent stem cells in vitro but efficiency of differentiation varies, making it hard to sort for insulin-producing cells. Here, the authors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ PPs.