Nature Communications (Jul 2020)
Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
- Eman Khatib-Massalha,
- Suditi Bhattacharya,
- Hassan Massalha,
- Adi Biram,
- Karin Golan,
- Orit Kollet,
- Anju Kumari,
- Francesca Avemaria,
- Ekaterina Petrovich-Kopitman,
- Shiri Gur-Cohen,
- Tomer Itkin,
- Isabell Brandenburger,
- Asaf Spiegel,
- Ziv Shulman,
- Zachary Gerhart-Hines,
- Shalev Itzkovitz,
- Matthias Gunzer,
- Stefan Offermanns,
- Ronen Alon,
- Amiram Ariel,
- Tsvee Lapidot
Affiliations
- Eman Khatib-Massalha
- Department of Immunology, Weizmann Institute of Science
- Suditi Bhattacharya
- Department of Immunology, Weizmann Institute of Science
- Hassan Massalha
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Adi Biram
- Department of Immunology, Weizmann Institute of Science
- Karin Golan
- Department of Immunology, Weizmann Institute of Science
- Orit Kollet
- Department of Immunology, Weizmann Institute of Science
- Anju Kumari
- Department of Immunology, Weizmann Institute of Science
- Francesca Avemaria
- Department of Immunology, Weizmann Institute of Science
- Ekaterina Petrovich-Kopitman
- Department of Immunology, Weizmann Institute of Science
- Shiri Gur-Cohen
- Department of Immunology, Weizmann Institute of Science
- Tomer Itkin
- Department of Immunology, Weizmann Institute of Science
- Isabell Brandenburger
- Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research
- Asaf Spiegel
- Department of Immunology, Weizmann Institute of Science
- Ziv Shulman
- Department of Immunology, Weizmann Institute of Science
- Zachary Gerhart-Hines
- Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
- Shalev Itzkovitz
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Matthias Gunzer
- Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen
- Stefan Offermanns
- Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research
- Ronen Alon
- Department of Immunology, Weizmann Institute of Science
- Amiram Ariel
- Department of Human Biology, University of Haifa
- Tsvee Lapidot
- Department of Immunology, Weizmann Institute of Science
- DOI
- https://doi.org/10.1038/s41467-020-17402-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increases endothelial barrier permeability and mobilization of these neutrophils by targeting endothelial GPR81.
