Терапевтический архив (Jul 2004)

Prognostic implication of a focal lesion of bone marrow in diffuse large В cell lymphosarcoma

  • A U Magomedova,
  • A M Kremenetskaya,
  • I A Vorobyev,
  • S K Kravchenko,
  • I В Kaplanskaya,
  • R S Samoilova,
  • E G Gemdzhyan,
  • A I Vorobyev

Journal volume & issue
Vol. 79, no. 7
pp. 60 – 63

Abstract

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Aim. To study prognostic implications of a focal mature cell lesion of the bone marrow (BM) in patients with diffuse large В cell lymphosarcoma (DBLCL). Material and methods. 54 patients with histologically confirmed DBLCL were given first-line CHOP and CHOP-like courses from 1996 to 2003. B-cell nature of the tumor was confirmed immunohistochemically, immunophenotypically and with flow fluorimetry. Results. In debute of the disease 16 patients had local involvement of the lymph organs (stage I-II by Enn-Arbor), 21 patients - generalized disease (stage III-IV) and 17 patients - involvement of nonlymphatic organs. Overall 3-year survival in first-line therapy in mature cell lesion of BM was 23%, without it - 0%. One-year event-free survival was 34 and 0%, respectively. Conclusion. The presence of a focal mature cell lesion of BM in DBLCL patients influences the prognosis. Regarding high frequency of transformation of mature cell lymphoproliferative diseases in DBLCL . focal lesion of BM is an indirect sign of a secondary nature of the disease.

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