Madurella mycetomatis infection following allogenic stem cell transplantation for aplastic anemia

Mediterranean Journal of Hematology and Infectious Diseases. 2012;4(1):e2012038-e2012038 DOI 10.4084/mjhid.2012.038

 

Journal Homepage

Journal Title: Mediterranean Journal of Hematology and Infectious Diseases

ISSN: 2035-3006 (Online)

Publisher: PAGEPress Publications

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs

Country of publisher: Italy

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS


Sanjeev Kumar Sharma (MD)

Anjan Mukherjee

Avinash Kumar Singh

Tuika Seth

Suman Kumar

Pravas Mishra

Immaculata Xess

Somesh Gupta

Manoranjan Mahapatra

Haraprasad Pati

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 12 weeks

 

Abstract | Full Text

Madurella mycetomatis is the most common fungal agent causing eumycetoma. The commonest clinical presentation of the infection is the appearance of multiple sinuses with discharge of grains, which are the colonies of the fungus. It is an emerging fungal infection among transplant recipients and has not been reported following stem cell transplantation. We report here a case of aplastic anemia who developed madura foot, caused by Madurella mycetomatis, following allogenic peripheral blood stem cell transplantation. The diagnosis was made by the examination of discharged black grains under microscope which reavaled presence of septate hyphae and the culture of the discharged granules grew Madurella mycetomatis. The patient was treated with voriconazole followed by excision of the lesion, which resulted in complete recovery. Considering the increasing number of patients undergoing stem cell transplantation for various hematological diseases, the implications of this fungal infection should be recognized as delay in treatment may be life-threatening.